Can Cannabidiol Help Prevent and Treat Gastrointestinal Disorders? Insights from Experts

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Many people search for a “cannabis store near me” to buy marijuana, whether for health management or recreational enjoyment. It is widely understood that cannabis products may help alleviate symptoms like anxiety, depression, pain, nausea, and vomiting. Have you considered its impact on gastrointestinal disorders?

Key Takeaways:

• Cannabinoids from the plant engage with the endocannabinoid system in the GI tract.
• Cannabis and pain management medications can assist in controlling Irritable Bowel Syndrome symptoms.
• cannabis serves multiple purposes, but is primarily recognized for its recreational and medicinal uses.

Gastrointestinal Disorders and The High Club Canada

The dietary impacts of nutraceuticals on GI health are well-established. Certain diets have the potential to prevent or lessen various GI issues. Researchers have identified and assessed the food components responsible for these benefits.

Among the plant-derived nutraceuticals that may help treat GI disorders are those sourced from cannabis. Cannabis refers to products derived from the cannabis Sativa plant, an aromatic flowering herb.

In a scientific review, John M. McPartland noted that the Cannabaceae family includes the genera Cannabis, Humulus, and Celtis. Within the cannabis genus, sativa has three varieties: Sativa, Indica, and Ruderalis. It’s important to recognize that cannabis sativa serves different functions depending on the variety, such as fiber production, oil extraction from seeds, and primarily, recreational or medical applications.

The Impact of cannabis

Receptors and ligands of the endocannabinoid system are distributed across various areas and systems, both within and outside the GI tract, which are essential for regulating GI functions. The presence of cannabinoid receptors allows cannabinoids, including non-psychoactive phytocannabinoids, to help modulate GI functions in both health and disease. The ECS plays a role in regulating motility, secretion, epithelial barrier function, and viscerosensitivity.

Irritable Bowel Syndrome (IBS)

IBS has numerous contributing factors and affects 10–20% of individuals in developed countries. It manifests as functional gastrointestinal disturbances without identifiable organic causes.

The enhancement of the antinociceptive properties of cannabinoids in the presence of inflammation highlights the ECS’s importance in visceral hypersensitivity. This finding not only provides insight into the mechanisms behind conditions like IBS but also suggests promising therapeutic options for alleviating abdominal and visceral pain.

Cannabinoids alone may not significantly relieve visceral hypersensitivity in IBS patients. Investigating combinations with other pain-relieving agents, such as opioids, presents an intriguing alternative worth exploring.

Inflammatory Bowel Disease (IBD)

IBD, including Crohn’s disease and ulcerative colitis, is a complex condition of the GI tract, stemming from environmental, genetic, and epigenetic factors.

Cannabidiol exhibits strong anti-inflammatory properties in various models of intestinal inflammation, as discussed in a study from the Journal of Frontiers in Pharmacology. Both local and systemic administration of CBD resulted in a dose-dependent improvement in disease markers:

• Reduction of structural damage
• Mitigation of inflammation-related increases in various cytokines, chemokines, and oxidative stress markers.

A study from the Inflammatory Diseases Journal found that the primary result of their investigation was the poor tolerability of the botanical extract, with 90% of patients reporting treatment-related adverse effects compared to 48% in the placebo group.

A trend emerged toward improved quality of life scores and a positive shift in patients’ overall impression of change, according to the per-protocol analysis. The authors speculate that the CBD-rich botanical extract might offer therapeutic benefits to those who can tolerate its effects.

Gastrointestinal Cancer

GI cancers, including colorectal cancer, are among the most frequently diagnosed conditions in the general population.

Multiple studies have demonstrated CBD’s antiproliferative effects in colorectal cancer models. CBD can protect DNA from oxidative stress, elevate endocannabinoid levels, and inhibit the proliferation of colorectal cancer cells in vitro.

The confirmation of CBD’s chemopreventive properties came from studies focusing on AOM-induced colon cancer. CBD at a dosage of 1 mg/kg led to a significant reduction: ACF decreased by 67%, while the number of tumors and polyps dropped by 66% and 57%, respectively. Increasing the dosage to 5 mg/kg was effective mainly in preventing polyps.

THC induces apoptosis in colorectal cancer cells by stimulating the CB1 receptor.

Nausea and Vomiting

CBD has positive effects when combined with THC, as indicated in research published in the British Journal of Clinical Pharmacology. CBD’s anti-nausea and anti-emetic effects may result from the indirect stimulation of somatodendritic 5-HT1A receptors located in the dorsal raphe nucleus, leading to decreased 5-HT release in specific forebrain areas.

Gastroesophageal Reflux Disease (GERD)

Cannabinoids impede transient LES relaxations through a CB1-dependent mechanism in both dogs and ferrets, according to a study from the Journal of Cannabis and Cannabinoid Research. These findings are significant as transient LES relaxations are the primary mechanism behind gastroesophageal reflux disease.

cannabis for GI Issues

Conclusion

Numerous studies suggest that the advantages of cannabinoids extend beyond the well-known psychoactive compound THC to include non-psychoactive substances like CBD, which have received less attention. The cannabis plant affects the GI system by interacting with the ECS to trigger various functions that may help manage symptoms of certain GI conditions.

Frequently Asked Questions

What can you expect when buying from The High Club Canada?

1. Purchasing cannabis online in Canada offers many choices, including both classic favorites and new products.
2. You can look forward to additional perks such as special promotions, secure payment methods, and shipping options across most provinces.
3. Valuable resources, such as a blog or contact page, are available to assist customers during their shopping experience.
4. During the purchase process, you’ll need to verify your age by providing identification.
5. Some stores include taxes in their product prices, while others calculate it during checkout.
6. Some dispensaries accept online payments like Interac E-Transfer, while others allow cash on delivery.

What is the measurement unit when buying from a cannabis website?

There are two main measurement systems: metric and imperial. On a cannabis site, you’ll find measurements in grams or ounces, which allows you to purchase products like 3.5 grams or 1/8 ounces.

What distinguishes cannabis for medical use from that used recreationally?

Medical and recreational cannabis come from the same plant species, but their differing effects and intended uses differentiate them. Medical cannabis is a therapeutic aid for specific health conditions, often with a higher CBD content compared to recreational cannabis.

Are there ready-made joints available in a cannabis store?

Yes. These come as pre-rolls. cannabis pre-rolls, or pre-rolled joints and blunts, are convenient options for those who want their cannabis ready to use. The popularity of pre-rolled joints infused with cannabis concentrates is on the rise.

Do cannabis online stores have a physical shop?

Not all online stores have physical locations, allowing you to have your purchases delivered directly to your home instead of needing to pick them up from a physical store after placing an order online.

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